Yaz, Yasmin Associated with Increased Risk of Blood Clots


Yaz, Yasmin Associated with Increased Risk of Blood ClotsOverview: When Yaz and Yasmin were first launched, they were marketed as the new generation of oral contraceptives for the modern woman. However, in recent years the heavily advertised birth control has sparked safety concerns over reports that the pills are associated with deadly blood clots.

  • Yaz contains drospirenone, synthetic hormone linked to an increased risk of blood clots
  • In April, the FDA updated the label on Yaz, Yasmin and other drospirenone-based birth control pills; studies show that women who use drospirenone-based birth control pills may be three times as likely to develop blood clots compared to women who used other types of birth control pills
  • Together, Yaz and Yasmin were named in more lawsuits than any other drug last year; there are over 12,000 Yaz, Yasmin cases in the US

Product: Yaz, Yasmin (Drospirenone and Ethinyl Estradiol)

Manufacturer: Bayer AG

Side Effects & Complications

  • Blood Clots
  • Pulmonary Embolism (PE)
  • Deep Vein Thrombosis (DVT)
  • Gallbladder Damage
  • Heart Attacks
  • Stroke

How Do Yaz, Yasmin Increase the Risk of Blood Clots?

Yaz, Yasmin and their generics (Gianvi, Ocella) contain drospirenone, a synthetic type of progestin. According to About.com, drospirenone may inhibit the hormones responsible for regulating water and electrolytes. Additionally, the substance can interfere with body’s potassium levels. All birth control pills carry some risk of blood clots, but studies suggest that the risk is higher in combined oral contraceptives.

Last March, a study in the British Medical Journal found a significantly higher rate of venous thromboembolism (VTE) among women who used birth control pills like Yaz or Yasmin. Researchers found an incidence of 23 per 100,000 person-years in the drospirenone group versus 9.1 among women who took pills with levonorgestrel.

In April, the U.S. Food and Drug Administration (FDA) updated the label on Yaz, Yasmin and other birth control pills containing drospirenone. The agency modified the information to include data from recent studies, some of which indicated a three-fold increased risk among drospirenone-based birth control users compared to women who used an alternative oral contraceptive.

Yaz Lawsuits

According to the Institute for Safe Medication Practices (ISMP)’s latest QuarterWatch Report, Yaz and Yasmin were named in more lawsuits than any other medication last year, and were involved in over 8,300 cases. In addition to blood clot-related to conditions, users also claimed that the birth control pills caused gallbladder disease.

Parker Waichman LLP, a national personal injury firm, filed one such lawsuit in May on behalf of two women. The suit was filed in the multidistrict litigation in the U.S. District Court for the Southern District of Illinois before Judge David R. Herndon (MDL No. 2100).