Study Links SlimQuick to Possible Liver Damage, Worsened by Genetic Predisposition

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Study Links SlimQuick to Possible Liver Damage, Worsened by Genetic PredispositionOverview: A recent study published in the World Journal of Hepatology links the weight loss product SlimQuick, to liver damage. Researchers noted that those with a genetic predisposition, indicated by the alpha-1 antitrypsin MZ phenotype may be more susceptible to this drug-induced liver injury (DILI).

Product: SlimQuick Fat Burner, SlimQuick Caffeine Free, SlimQuick Razor

Manufacturer: Wellnx Life Sciences

Side Effects & Complications

  • Liver failure
  • Liver injury
  • Nausea
  • Abdominal pain
  • Jaundice

 

SlimQuick Associated with Liver Damage

The study is based on a case-report of a 24-year old woman who took SlimQuick for three months before developing worrisome symptoms such as dark urine, acholic stools, abdominal pain and progressive fatigue. After a series of tests assessing liver function, she presented with the following results:

Test Result Normal Range
Serum alanine aminotransferase (ALT) 2615 IU/L 7-56 IU/L
Alkaline phosphatase (ALP) 200 IU/L 20-140 IU/L
Total bilirubin level 4.0 mg/dL  0.1-1.0 mg/dL
Prothrombin time/ international normalized ratio (INR) 12 seconds/ 1.2 10-13 seconds/ 0.8-1.2

 

According to previous tests cited in the case report, the woman’s ALT, ALP and total bilirubin levels were normal prior to using SlimQuick. Researchers stated that the “liver biopsy was consistent with marked inflammation with necrosis”. Her condition persisted three weeks after stopping SlimQuick, prompting doctors to pursue treatment with Prednisone; this greatly improved her levels, and liver function returned to normal.

The authors establish green tea extract (camellia sinensis leaf) as the likely factor contributing to the drug-induced liver injury. Green tea extract contains high levels of EGCG, a substance that “has pro-oxidant effects that can cause hepatotoxicity when administered at high doses.”

Genetic Predisposition

It should be noted that the patient was identified as having alpha-1 antitrypsin MZ phenotype, indicating that she may have a slightly increased risk of impaired liver function. “This demonstrates the importance of seeking underlying susceptibility to hepatic injury in previously healthy subjects to develop DILI”, the authors stated.

Alpha-1 antitrypsin deficiency is protease inhibitor; it moderates the activity of powerful enzymes that break down foreign chemicals. Those with alpha-1 antitrypsin deficiency are therefore more susceptible to liver and lung injuries. Most of the population carries two copies of the normal gene, or are “MM” (homozygous for alpha-1 antitrypsin). The “Z” and “S” versions of the gene (alleles) indicate very low and moderately low levels of alpa-1 antitrypsin, respectively. Therefore, those with “ZZ”, “SZ” or “SS” are at the greatest risk of developing deficiency. An MZ phenotype, seen in this study, indicated a slightly increased risk.

Background

SlimQuick is a weight loss product comprised of six different “complexes”. The ingredients and intended uses are listed below.

  • Aquaplex Complex: dandelion root, horsetail herb extract, uva ursi extract, French maritime pine bark extract
    • Diuretic properties
  • Cortifern Complex: beta sitosterol, phosphatidylserine, rhidiola rosea roots, theanine
    • Lowering stress hormones
  • Cyclovite Complex: calcium, folic acid, vitamin B6, vitamin B12, and vitamin D
    • Improving overall health
  • Estrotrim Complex: soy isoflavones
    • Hormonal regulation
  • Nutratherm Complex: green tea extract, caffeine, cocoa bean extract, yerba mate leaf extract, and clary sage root
    • Increase metabolic rate and energy
  • Xtend Complex: cellulose ethers and piper nigum
    • Increases metabolic rate and facilitates absorption of other ingredients

SlimQuick’s safety label lists symptoms of liver damage such as abdominal pain, jaundice, nausea and dark urine but does not explicitly warn users about the risk of liver damage.